Article
Association between a polymorphic variant in the CDKN2B-AS1/ANRIL gene and pancreatic cancer risk.
International journal of cancer - 15 Jul 2023
Giaccherini Matteo, Farinella Riccardo, Gentiluomo Manuel, Mohelnikova-Duchonova Beatrice, Kauffmann Emanuele Federico, Palmeri Matteo, Uzunoglu Faik, Soucek Pavel, Petrauskas Dalius, Cavestro Giulia Martina, Zykus Romanas, Carrara Silvia, Pezzilli Raffaele, Puzzono Marta, Szentesi Andrea, Neoptolemos John, Archibugi Livia, Palmieri Orazio, Milanetto Anna Caterina, Capurso Gabriele, van Eijck Casper H J, Stocker Hannah, Lawlor Rita T, Vodicka Pavel, Lovecek Martin, Izbicki Jakob R, Perri Francesco, Kupcinskaite-Noreikiene Rita, Götz Mara, Kupcinskas Juozas, Hussein Tamás, Hegyi Péter, Busch Olivier R, Hackert Thilo, Mambrini Andrea, Brenner Hermann, Lucchesi Maurizio, Basso Daniela, Tavano Francesca, Schöttker Ben, Vanella Giuseppe, Bunduc Stefania, Petrányi Ágota, Landi Stefano, Morelli Luca, Canzian Federico, Campa Daniele
Abstract excerpt
Genes carrying high-penetrance germline mutations may also be associated with cancer susceptibility through common low-penetrance genetic variants. To increase the knowledge on genetic pancreatic ductal adenocarcinoma (PDAC) aetiology, the common genetic variability of PDAC familial genes was analysed in our study. We conducted a multiphase study analysing 7745 single nucleotide polymorphisms (SNPs) from 29 genes...
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