Common germline variants within the CDKN2A/2B region affect risk of pancreatic neuroendocrine tumors.

doi:10.1038/srep39565

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Article

Common germline variants within the CDKN2A/2B region affect risk of pancreatic neuroendocrine tumors.

Scientific reports - 23 Dec 2016

Campa Daniele, Capurso Gabriele, Pastore Manuela, Talar-Wojnarowska Renata, Milanetto Anna Caterina, Landoni Luca, Maiello Evaristo, Lawlor Rita T, Malecka-Panas Ewa, Funel Niccola, Gazouli Maria, De Bonis Antonio, Klüter Harald, Rinzivillo Maria, Delle Fave Gianfranco, Hackert Thilo, Landi Stefano, Bugert Peter, Bambi Franco, Archibugi Livia, Scarpa Aldo, Katzke Verena, Dervenis Christos, Liço Valbona, Furlanello Sara, Strobel Oliver, Tavano Francesca, Basso Daniela, Kaaks Rudolf, Pasquali Claudio, Gentiluomo Manuel, Rizzato Cosmeri, Canzian Federico

Abstract excerpt

Pancreatic neuroendocrine tumors (PNETs) are heterogeneous neoplasms which represent only 2% of all pancreatic neoplasms by incidence, but 10% by prevalence. Genetic risk factors could have an important role in the disease aetiology, however only a small number of case control studies have been performed yet. To further our knowledge, we genotyped 13 SNPs belonging to the pleiotropic CDKN2A/B gene region in 320...

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PMID: 28008994
DOI: 10.1038/srep39565
PMCID: PMC5180167

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