Article
Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations.
Nature communications - 11 Sept 2018
Chang Jiang, Tian Jianbo, Zhu Ying, Zhong Rong, Zhai Kan, Li Jiaoyuan, Ke Juntao, Han QiangQiang, Lou Jiao, Chen Wei, Zhu Beibei, Shen Na, Zhang Yi, Gong Yajie, Yang Yang, Zou Danyi, Peng Xiating, Zhang Zhi, Zhang Xuemei, Huang Kun, Yang Ming, Wang Li, Wu Chen, Lin Dongxin, Miao Xiaoping
Abstract excerpt
Germline coding variants have not been systematically investigated for pancreatic ductal adenocarcinoma (PDAC). Here we report an exome-wide investigation using the Illumina Human Exome Beadchip with 943 PDAC cases and 3908 controls in the Chinese population, followed by two independent replicate samples including 2142 cases and 4697 controls. We identify three low-frequency missense variants associated with the...
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