Common genetic variants associated with pancreatic adenocarcinoma may also modify risk of pancreatic neuroendocrine neoplasms.

doi:10.1093/carcin/bgx150

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Article

Common genetic variants associated with pancreatic adenocarcinoma may also modify risk of pancreatic neuroendocrine neoplasms.

Carcinogenesis - 8 Mar 2018

Obazee Ofure, Capurso Gabriele, Tavano Francesca, Archibugi Livia, De Bonis Antonio, Greenhalf William, Key Tim, Pasquali Claudio, Milanetto Anna Caterina, Hackert Thilo, Fogar Paola, Liço Valbona, Dervenis Christos, Lawlor Rita T, Landoni Luca, Gazouli Maria, Zambon Carlo Federico, Funel Niccola, Strobel Oliver, Jamroziak Krzysztof, Cantù Cinzia, Malecka-Panas Ewa, Landi Stefano, Neoptolemos John P, Basso Daniela, Talar-Wojnarowska Renata, Rinzivillo Maria, Andriulli Angelo, Canzian Federico, Campa Daniele

Abstract excerpt

Pancreatic neuroendocrine neoplasms (pNEN) account for less than 5% of all pancreatic neoplasms and genetic association studies on susceptibility to the disease are limited. We sought to identify possible overlap of genetic susceptibility loci between pancreatic ductal adenocarcinoma (PDAC) and pNEN; therefore, PDAC susceptibility variants (n = 23) from Caucasian genome-wide association studies (GWAS) were...

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PMID: 29309705
DOI: 10.1093/carcin/bgx150

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