Article
A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma.
Mutagenesis - 15 Mar 2025
Giaccherini Matteo, Rende Mariaconcetta, Gentiluomo Manuel, Corradi Chiara, Archibugi Livia, Ermini Stefano, Maiello Evaristo, Morelli Luca, van Eijck Casper H J, Cavestro Giulia Martina, Schneider Marton, Mickevicius Antanas, Adamonis Kestutis, Basso Daniela, Hlavac Viktor, Gioffreda Domenica, Talar-Wojnarowska Renata, Schöttker Ben, Lovecek Martin, Vanella Giuseppe, Gazouli Maria, Uno Miyuki, Malecka-Wojciesko Ewa, Vodicka Pavel, Goetz Mara, Bijlsma Marteen F, Petrone Maria Chiara, Bazzocchi Francesca, Kiudelis Mindaugas, Szentesi Andrea, Carrara Silvia, Nappo Gennaro, Brenner Hermann, Milanetto Anna Caterina, Soucek Pavel, Katzke Verena, Peduzzi Giulia, Rizzato Cosmeri, Pasquali Claudio, Chen Xuechen, Capurso Gabriele, Hackert Thilo, Bueno-de-Mesquita Bas, Uzunoglu Faik G, Hegyi Peter, Greenhalf William, Theodoropoulos George E, Sperti Cosimo, Perri Francesco, Oliverius Martin, Mambrini Andrea, Tavano Francesca, Farinella Riccardo, Arcidiacono Paolo Giorgio, Lucchesi Maurizio, Bunduc Stefania, Kupcinskas Juozas, Di Franco Gregorio, Stocker Hannah, Neoptolemos John P, Bambi Franco, Jamroziak Krzysztof, Testoni Sabrina G G, Aoki Mateus N, Mohelnikova-Duchonova Beatrice, Izbicki Jacob R, Pezzilli Raffaele, Lawlor Rita T, Kauffmann Emanuele F, López de Maturana Evangelina, Malats Nuria, Canzian Federico, Campa Daniele
Abstract excerpt
Pleiotropic variants (i.e. genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants was successfully conducted 10 years ago in relation to pancreatic ductal adenocarcinoma susceptibility. However, in the last decade, genetic association studies performed on several human traits have greatly increased the number of known pleiotropic variants....
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