Article

KCC2 as a novel biomarker and therapeutic target for motoneuron degenerative disease

2023-08-25

Abstract excerpt

Hyperexcitability in cells throughout the corticospinal tract is a presymptomatic feature of amyotrophic lateral sclerosis (ALS) associated with lethal motor degeneration 1–6 . Disinhibition is a possible cause of this hyperexcitability, potentially implicating the central nervous system-specific potassium-chloride cotransporter, KCC2, a core regulator of the strength of GABAergic neurotransmission linked to seve...

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Literature Corpus work: 805ac818-9b46-5322-ad10-365a30a8732a
DOI: 10.1101/2023.08.24.554410

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