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Article

Refining the genetic risk of breast cancer with rare haplotypes and pattern mining.

Life science alliance - 1 Oct 2023

Letsou William, Wang Fan, Moon Wonjong, Im Cindy, Sapkota Yadav, Robison Leslie L, Yasui Yutaka

Abstract excerpt

Hundreds of common variants have been found to confer small but significant differences in breast cancer risk, supporting the widely accepted polygenic model of inherited predisposition. Using a novel closed-pattern mining algorithm, we provide evidence that rare haplotypes may refine the association of breast cancer risk with common germline alleles. Our method, called Chromosome Overlap, consists in iteratively...

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Identifiers

PMID: 37541849
DOI: 10.26508/lsa.202302183
PMCID: PMC10403637

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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