Article

Potential Misrepresentation of Inherited Breast Cancer Risk by Common Germline Alleles

2022-10-22

Abstract excerpt

Hundreds of common variants have been found to confer small but significant differences in breast cancer risk, supporting the polygenic additive model of inherited risk. This widely accepted model is at odds with twin data indicating highly elevated risk in a subgroup of women. Using a novel closed-pattern-mining algorithm, we provide evidence that rare variants or haplotypes may underlie the association of breast...

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Literature Corpus work: bbccd2b9-04ac-5a49-9a36-ee075bd536c7
DOI: 10.1101/2022.10.21.22281361

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