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Swedish Genome-Wide Haplotype Association Analysis Suggests Breast Cancer Loci with Varying Risk-Modifying Effects.

Genes - 17 Dec 2024

Vermani Litika, Barnekow Elin, Liu Wen, Wendt Camilla, Hall Per, Margolin Sara, Lindblom Annika

Abstract excerpt

Background: To find support for risk-modifying genes in breast cancer, a haplotype GWAS in sporadic breast cancer cases was undertaken. The results were compared with the results from previous analyses in familial cases and all cases from the same Swedish cohort. Methods: In total, 2550 women with sporadic invasive breast cancer and 5021 healthy controls were included in a sliding-window haplotype GWAS using...

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PMID: 39766883
DOI: 10.3390/genes15121616
PMCID: PMC11675172

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