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Article

LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry.

Journal of neuropathology and experimental neurology - 21 Aug 2023

Katsumata Yuriko, Fardo David W, Shade Lincoln M P, Nelson Peter T

Abstract excerpt

Limbic-predominant age-related TDP-43 encephalopathy (LATE) affects approximately one-third of older individuals and is associated with cognitive impairment. However, there is a highly incomplete understanding of the genetic determinants of LATE neuropathologic changes (LATE-NC) in diverse populations. The defining neuropathologic feature of LATE-NC is TDP-43 proteinopathy, often with comorbid hippocampal...

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Aging
Alzheimer Disease
Dementia
Membrane Proteins
Nerve Tissue Proteins

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TDP-43 Proteinopathies

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PMID: 37528055
DOI: 10.1093/jnen/nlad059
PMCID: PMC10440720

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