Article
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.
JAMA - 10 Apr 2013
Reitz Christiane, Jun Gyungah, Naj Adam, Rajbhandary Ruchita, Vardarajan Badri Narayan, Wang Li-San, Valladares Otto, Lin Chiao-Feng, Larson Eric B, Graff-Radford Neill R, Evans Denis, De Jager Philip L, Crane Paul K, Buxbaum Joseph D, Murrell Jill R, Raj Towfique, Ertekin-Taner Nilufer, Logue Mark, Baldwin Clinton T, Green Robert C, Barnes Lisa L, Cantwell Laura B, Fallin M Daniele, Go Rodney C P, Griffith Patrick, Obisesan Thomas O, Manly Jennifer J, Lunetta Kathryn L, Kamboh M Ilyas, Lopez Oscar L, Bennett David A, Hendrie Hugh, Hall Kathleen S, Goate Alison M, Byrd Goldie S, Kukull Walter A, Foroud Tatiana M, Haines Jonathan L, Farrer Lindsay A, Pericak-Vance Margaret A, Schellenberg Gerard D, Mayeux Richard
Abstract excerpt
IMPORTANCE: Genetic variants associated with susceptibility to late-onset Alzheimer disease are known for individuals of European ancestry, but whether the same or different variants account for the genetic risk of Alzheimer disease in African American individuals is unknown. Identification of disease-associated variants helps identify targets for genetic testing, prevention, and treatment. OBJECTIVE: To identify...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.