Article
Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2016
Schott Jonathan M, Crutch Sebastian J, Carrasquillo Minerva M, Uphill James, Shakespeare Tim J, Ryan Natalie S, Yong Keir X, Lehmann Manja, Ertekin-Taner Nilufer, Graff-Radford Neill R, Boeve Bradley F, Murray Melissa E, Khan Qurat Ul Ain, Petersen Ronald C, Dickson Dennis W, Knopman David S, Rabinovici Gil D, Miller Bruce L, González Aida Suárez, Gil-Néciga Eulogio, Snowden Julie S, Harris Jenny, Pickering-Brown Stuart M, Louwersheimer Eva, van der Flier Wiesje M, Scheltens Philip, Pijnenburg Yolande A, Galasko Douglas, Sarazin Marie, Dubois Bruno, Magnin Eloi, Galimberti Daniela, Scarpini Elio, Cappa Stefano F, Hodges John R, Halliday Glenda M, Bartley Lauren, Carrillo Maria C, Bras Jose T, Hardy John, Rossor Martin N, Collinge John, Fox Nick C, Mead Simon
Abstract excerpt
INTRODUCTION: The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain. METHODS: We genotyped 302 PCA patients from 11 centers, calculated risk at 24 loci for AD/DLB and performed an exploratory genome-wide association study. RESULTS: We confirm that variation in/near APOE/TOMM40 (P = 6 × 10(-14)) alters PCA risk, but with smaller effect than...
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