TMEM106B is a selective modulator of TDP-43 pathology in Alzheimer's disease.

doi:10.1002/alz.71713

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Article

TMEM106B is a selective modulator of TDP-43 pathology in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2026

Reeves Madison M, Calliari Anna, Todd Tiffany W, Maroto Cidfuentes Candela, Jansen-West Karen, Yue Mei, Song Yuping, Dunmore Judith, Rawlinson Bailey, Engelberg-Cook Erica, DeTure Michael, Day Gregory S, Graff-Radford Neill R, Boeve Bradley F, Knopman David S, Petersen Ronald C, Cook Casey N, Murray Melissa E, Dickson Dennis W, Josephs Keith A, Petrucelli Leonard, Prudencio Mercedes

Abstract excerpt

INTRODUCTION: Co-pathologies - including Lewy body, vascular, and TDP-43 lesions - are common in Alzheimer's disease (AD), contributing to its clinical and pathological heterogeneity. Genetic risk factors may drive mixed pathology presentation, but their influence on the development of specific co-pathologies remains unclear. METHODS: We evaluated the TMEM106B coding variant rs3173615 and apolipoprotein E...

Read the complete abstract on PubMed

Topics

Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Alzheimer Disease

DNA-Binding Proteins

Membrane Proteins

Female

Nerve Tissue Proteins

Brain

Male

Aged

Aged, 80 and over

Polymorphism, Single Nucleotide

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 42720122
DOI: 10.1002/alz.71713
PMCID: PMC13559991

Genes

TMEM106B
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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