Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GRN rs5848 variant associates with TDP-43 pathology and cancer in opposite directions.

Journal of neuropathology and experimental neurology - 1 Sept 2026

Aung Khine Zin, Nelson Peter T, Ning Xiaotong, Wu Xian, Tsuchiya Inori, Karanth Shama, Abner Erin L, Fardo David W, Katsumata Yuriko

Abstract excerpt

Epidemiologic studies have reported that cancer survivors have a relatively low risk of developing dementia, but the mechanisms underlying that inverse relationship are mostly unknown. The Granulin (GRN) gene single nucleotide variant rs5848 T allele is associated with increased risk of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and hippocampal sclerosis of aging...

Read the complete abstract on PubMed

Topics

Humans
Progranulins
Intercellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Female

Neoplasms

Male

DNA-Binding Proteins

Genetic Predisposition to Disease

Aged

TDP-43 Proteinopathies

Aged, 80 and over

Aging

Hippocampal Sclerosis

Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 42168777
DOI: 10.1093/jnen/nlag051
PMCID: PMC13314055

Genes

GRN
APOE
BIN1
TMEM106B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GRN rs5848 variant associates with TDP-43 pathology and cancer in opposite directions.PMID 42168777Read ↗

Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly.Semantic proximity Read ↗

Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study.Semantic proximity Read ↗

Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia.Semantic proximity Read ↗

Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease.Semantic proximity Read ↗

Clinical variability and onset age modifiers in an extended Belgian GRN founder familySemantic proximity Read ↗

LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry.Semantic proximity Read ↗

Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2Semantic proximity Read ↗

The TMEM106B locus and TDP-43 pathology in older persons without FTLD.Semantic proximity Read ↗

Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels.Semantic proximity Read ↗

rs5848 polymorphism and serum progranulin level.Semantic proximity Read ↗

Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease.Semantic proximity Read ↗

The granulin gene family: from cancer to dementiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.