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Article

Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer's pathologies.

Acta neuropathologica - 15 Nov 2024

Katsumata Yuriko, Wu Xian, Aung Khine Zin, Fardo David W, Woodworth Davis C, Sajjadi S Ahmad, Tomé Sandra O, Thal Dietmar Rudolf, Troncoso Juan C, Chang Koping, Mock Charles, Nelson Peter T

Abstract excerpt

Pure limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (pure LATE-NC) is a term used to describe brains with LATE-NC but lacking intermediate or severe levels of Alzheimer's disease neuropathologic changes (ADNC). Focusing on pure LATE-NC, we analyzed data from the National Alzheimer's Coordinating Center (NACC) Neuropathology Data Set, comprising clinical and pathological information...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39546031
DOI: 10.1007/s00401-024-02821-y
PMCID: PMC11568059

Genes

APOE
BIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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