Article
An impaired splicing program underlies differentiation defects in hSOD1G93A neural progenitor cells.
Cellular and molecular life sciences : CMLS - 31 Jul 2023
Verdile Veronica, Riccioni Veronica, Guerra Marika, Ferrante Gabriele, Sette Claudio, Valle Cristiana, Ferri Alberto, Paronetto Maria Paola
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is an adult devastating neurodegenerative disease characterized by the loss of upper and lower motor neurons (MNs), resulting in progressive paralysis and death. Genetic animal models of ALS have highlighted dysregulation of synaptic structure and function as a pathogenic feature of ALS-onset and progression. Alternative pre-mRNA splicing (AS), which allows expansion of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.