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Integrated profiling of iPSC-derived motor neurons carrying C9orf72, FUS, TARDBP, or SOD1 mutations.

Stem cell reports - 14 Oct 2025

Ma Guo-Ming, Xia Cong-Cong, Lyu Bo-Yu, Liu Jie, Luo Fang, Guan Ming-Feng, Wang Jun-Ying, Sun Li, Zhang Lin, Chen Yan, Mao Ying-Wei, Yu Guo-Qiang, Wang Wen-Yuan

Abstract excerpt

Here, we conducted temporal RNA sequencing (RNA-seq) profiling of human induced pluripotent stem cells (hiPSCs) and induced pluripotent stem cell (iPSC)-derived motor neurons (iMNs) carrying C9orf72, FUS, TARDBP, or SOD1 mutations in both patients with amyotrophic lateral sclerosis (ALS) and healthy individuals. We discovered dysregulated gene expression and alternative splicing (AS) throughout iMN development...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41043426
DOI: 10.1016/j.stemcr.2025.102649
PMCID: PMC12790725

Genes

FUS
SOD1
TARDBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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