Article

Post-transcriptional remodelling is temporally deregulated during motor neurogenesis in human ALS models

2017-08-24

Abstract excerpt

<h4>SUMMARY</h4> Mutations causing amyotrophic lateral sclerosis (ALS) strongly implicate regulators of RNA-processing that are ubiquitously expressed throughout development. To understand the molecular impact of ALS-causing mutations on early neuronal development and disease, we performed transcriptomic analysis of differentiated human control and VCP-mutant induced pluripotent stem cells (iPSCs) during motor ne...

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Literature Corpus work: e4073672-0e20-5351-b208-e6f74122374d
DOI: 10.1101/180372

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