Article

ALS sensitive spinal motor neurons enter a degenerative downward spiral of impaired splicing and proteostasis

2022-03-27

Abstract excerpt

Despite clear therapeutic potential, the mechanisms that confer differential neuronal sensitivity are not well understood. During Amyotrophic Lateral Sclerosis (ALS), sensitive spinal motor neurons (SpMN) die while a subset of rostral cranial motor neurons (CrMN) survive. In this work, we optimized a protocol to differentiate CrMNs and SpMNs from human induced pluripotent stem cells (iPSCs) by direct programming a...

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Literature Corpus work: ee41afe4-9434-56fa-9f16-c53499405b5b
DOI: 10.1101/2022.03.26.485939

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