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Article

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.

Cancer research - 1 Jul 2010

Gottipati Ponnari, Vischioni Barbara, Schultz Niklas, Solomons Joyce, Bryant Helen E, Djureinovic Tatjana, Issaeva Natalia, Sleeth Kate, Sharma Ricky A, Helleday Thomas

Abstract excerpt

Poly(ADP-ribose) (PAR) polymerase 1 (PARP1) is activated by DNA single-strand breaks (SSB) or at stalled replication forks to facilitate DNA repair. Inhibitors of PARP efficiently kill breast, ovarian, or prostate tumors in patients carrying hereditary mutations in the homologous recombination (HR) genes BRCA1 or BRCA2 through synthetic lethality. Here, we surprisingly show that PARP1 is hyperactivated in...

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Source

Identifiers

PMID: 20551068
DOI: 10.1158/0008-5472.CAN-09-4716

Genes

BRCA2
PARP1
SSB
BLM
BRCA1
RAD52
WRN
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.PMID 20551068Read ↗

Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination.Semantic proximity Read ↗

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Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer TherapySemantic proximity Read ↗

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Histone γH2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic BiomarkersSemantic proximity Read ↗

PARP1-Driven Poly-ADP-Ribosylation Regulates BRCA1 Function in Homologous Recombination–Mediated DNA RepairSemantic proximity Read ↗

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