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Article

SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy.

BMC cancer - 21 Jul 2023

Zheng Xiaobin, Lin Jing, Xiong Jiani, Guan Yanfang, Lan Bin, Li Yi, Gao Xuan, Fei Zhaodong, Chen Lisha, Chen Lizhu, Chen Ling, Chen Gang, Guo Zengqing, Yi Xin, Cao Weiguo, Ai Xinghao, Zhou Chengzhi, Li Xiaofeng, Zhao Jun, Yan Xiangtao, Yu Qitao, Si Lu, Chen Yu, Chen Chuanben

Abstract excerpt

BACKGROUND: SETD2 protects against genomic instability via maintenance of homologous recombination repair (HRR) and mismatch repair (MMR) in neoplastic cells. However, it remains unclear whether SETD2 dysfunction is a complementary or independent factor to microsatellite instability-high (MSI-H) and tumor mutational burden-high (TMB-H) for immunocheckpoint inhibitor (ICI) treatment, and little is known regarding...

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Identifiers

PMID: 37479966
DOI: 10.1186/s12885-023-10920-4
PMCID: PMC10360270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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