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Article

Genomic Alterations in DNA Mismatch Repair Genes Across Different Cancer Types.

JCO precision oncology - 1 Nov 2024

Holla Vijaykumar R, Kahle Michael P, Kim Sun-Hee, Ronaghy Arash, Yang Richard K, Patel Keyur P, Routbort Mark J, Overman Michael J, Dumbrava Ecaterina E, Mills Shaw Kenna R, Karp Daniel D, Meric-Bernstam Funda

Abstract excerpt

PURPOSE: PD-1 inhibition is effective in patients with mismatch repair deficient (dMMR) solid tumors in a tumor-agnostic fashion. However, dMMR testing by immunohistochemistry (IHC) is not routinely performed across tumor types. By contrast, next-generation sequencing (NGS) for somatic genomic alterations is frequently performed across tumor types. We hypothesized that NGS would identify patients with alterations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39576951
DOI: 10.1200/PO-24-00419
PMCID: PMC11825140

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