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Evaluation of 30 DNA damage response and 6 mismatch repair gene mutations as biomarkers for immunotherapy outcomes across multiple solid tumor types

1 Jan 2021

Abstract excerpt

OBJECTIVE: DNA damage response (DDR) genes have low mutation rates, which may restrict their clinical applications in predicting the outcomes of immune checkpoint inhibitor (ICI) treatment. Thus, a systemic analysis of multiple DDR genes is needed to identify potential biomarkers of ICI efficacy. METHODS: A total of 39,631 patients with mutation data were selected from the cBioPortal database. A total of 155...

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Cancer Immunotherapy and Biomarkers
Ferroptosis and cancer prognosis
Genetic factors in colorectal cancer

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33960179
DOI: 10.20892/j.issn.2095-3941.2020.0351

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