Article

Predicting response to immune checkpoint blockade therapy among mismatch repair-deficient patients using mutational signatures

2024-01-21

Abstract excerpt

<h4>ABSTRACT</h4> Despite the overall efficacy of immune checkpoint blockade (ICB) for mismatch repair deficiency (MMRD) across tumor types, a sizable fraction of patients with MMRD still do not respond to ICB. We performed mutational signature analysis of panel sequencing data (n = 95) from MMRD cases treated with ICB. We discover that T>C-rich single base substitution (SBS) signatures—SBS26 and SBS54 from the CO...

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Literature Corpus work: 49a2bba4-490b-5a91-97b5-19b748a3ee45
DOI: 10.1101/2024.01.19.24301236

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