Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical and histopathologic characterization of SETD2-mutated colorectal cancer.

Human pathology - 1 Jan 2023

Bushara Omar, Wester James R, Jacobsen Danielle, Sun Leyu, Weinberg Samuel, Gao Juehua, Jennings Lawrence J, Wang Lu, Lauberth Shannon M, Yue Feng, Liao Jie, Yang Guang-Yu

Abstract excerpt

With the advent of next-generation sequencing (NGS), identifying and better understanding genetic mutations in cancer pathways has become more feasible. A mutation now commonly reported in NGS panels is the SETD2 gene (H3K36 trimethyltransferase). However, its contributions to colorectal cancer (CRC) are not well described. In this study, we describe the clinicopathologic characteristics of SETD2-mutated CRC,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Epigenetics and DNA Methylation

Share to Genetic factors in colorectal cancer

Share to Histones

Share to Mutation

Share to RNA modifications and cancer

Source

Open in PubMed Open full text

Identifiers

PMID: 36502925
DOI: 10.1016/j.humpath.2022.12.001
PMCID: PMC9875556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical and histopathologic characterization of SETD2-mutated colorectal cancer.PMID 36502925Read ↗

SETD2 histone modifier loss in aggressive GI stromal tumours.Semantic proximity Read ↗

SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.Semantic proximity Read ↗

Correlation of KMT2 family mutations with molecular characteristics and prognosis in colorectal cancer.Semantic proximity Read ↗

Distinct Molecular and Prognostic Profiles of Left- and Right-Sided Colorectal Cancer Revealed by NGS Analysis: The Role of SMAD4 and SETD2 Mutations.Semantic proximity Read ↗

SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy.Semantic proximity Read ↗

Mutation and expression alterations of histone methylation-related NSD2, KDM2B and SETMAR genes in colon cancers.Semantic proximity Read ↗

Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations.Semantic proximity Read ↗

Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapySemantic proximity Read ↗

Loss of Function SETD2 Mutations in Poorly Differentiated Metastases from Two Hürthle Cell Carcinomas of the ThyroidSemantic proximity Read ↗

SETD2: an epigenetic modifier with tumor suppressor functionality.Semantic proximity Read ↗

Effects of KMT2D mutation and its exon 39 mutation on the immune microenvironment and drug sensitivity in colorectal adenocarcinomaSemantic proximity Read ↗

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.