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Article

IRF4 is required for migration of CD4+ T cells to the intestine but not for Th2 and Th17 cell maintenance

3 Jul 2023

Abstract excerpt

The transcription factor Interferon Regulatory Factor 4 (IRF4) is central in control of T cell activation and differentiation. Deficiency of IRF4 results in severe immune deficiency and affects maturation and function of most if not all T cell subsets. Here we use mouse infection models for Citrobacter rodentium and Strongyloides ratti to analyze the function of IRF4 in T helper (Th) 17 and Th2 cell responses,...

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Identifiers

PMID: 37469513
DOI: 10.3389/fimmu.2023.1182502

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