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Article

Elucidating different pattern of immunoregulation in BALB/c and C57BL/6 mice and their F1 progeny.

Scientific reports - 15 Jan 2021

Hartmann Wiebke, Blankenhaus Birte, Brunn Marie-Luise, Meiners Jana, Breloer Minka

Abstract excerpt

Helminths are large multicellular parasites that infect one quarter of the human population. To prolong their survival, helminths suppress the immune responses of their hosts. Strongyloides ratti delays its expulsion from the gut by induction of regulatory circuits in a mouse strain-specific manner: depletion of Foxp3+ regulatory T cells (Treg) improves the anti-S. ratti immunity in BALB/c but not in C57BL/6...

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Identifiers

PMID: 33452272
DOI: 10.1038/s41598-020-79477-7
PMCID: PMC7810711

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