Article

GATA4 regionalizes intestinal metabolism and barrier function to prevent immunopathology

2021-10-28

Abstract excerpt

<h4>Summary</h4> Different regions of the gastrointestinal tract have distinct digestive and absorptive functions, which may be locally disrupted by infection or autoimmune disease. Yet, the mechanisms underlying intestinal regionalization and its dysregulation in disease are not well understood. Here, we used mouse models, transcriptomics, and immune profiling to show that regional epithelial expression of the t...

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Literature Corpus work: 2ca17eec-a526-51f9-b071-a3e74ac3ae12
DOI: 10.1101/2021.10.28.466194

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