Article

A regulatory TRIF/IL-1R1 axis controls T-dependent IgA production in the intestines

2026-05-26

Abstract excerpt

<h4>SUMMARY</h4> Mucosal IgA is critical for controlling the microbiota and preventing pathogenic infection of the epithelium. The innate signals that regulate the generation of IgA remain poorly defined. Here, we identified TRIF and IL-1R1 as immune checkpoints for intestinal IgA production. In the absence of infection, Trif −/− and Il1r1 −/− mice exhibited markedly elevated stool IgA and IgA-bound commensal...

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Literature Corpus work: c144cdb7-691a-5b19-847c-bf7f03dea259
DOI: 10.64898/2026.05.22.725254

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