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Article

The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells.

Immunity - 20 Mar 2014

Yagi Ryoji, Zhong Chao, Northrup Daniel L, Yu Fang, Bouladoux Nicolas, Spencer Sean, Hu Gangqing, Barron Luke, Sharma Suveena, Nakayama Toshinori, Belkaid Yasmine, Zhao Keji, Zhu Jinfang

Abstract excerpt

Innate lymphoid cells (ILCs) are critical in innate immune responses to pathogens and lymphoid organ development. Similar to CD4(+) T helper (Th) cell subsets, ILC subsets positive for interleukin-7 receptor α (IL-7Rα) produce distinct sets of effector cytokines. However, the molecular control of IL-7Rα(+) ILC development and maintenance is unclear. Here, we report that GATA3 was indispensable for the development...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24631153
DOI: 10.1016/j.immuni.2014.01.012
PMCID: PMC4026797

Genes

GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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