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Article

IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo

9 Feb 2011

Abstract excerpt

BACKGROUND: The transcription factor IRF4 is involved in several T-cell-dependent chronic inflammatory diseases. To elucidate the mechanisms for pathological cytokine production in colitis, we addressed the role of the IRF transcription factors in human inflammatory bowel disease (IBD) and experimental colitis. METHODS: IRF levels and cytokine production in IBD patients were studied as well as the effects of IRF4...

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PMID: 21305677
DOI: 10.1002/ibd.21476

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