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Article

The ribonuclease domain function is dispensable for SLFN11 to mediate cell fate decision during replication stress response.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 2023

Qi Fei, Alvi Erin, Ogawa Minori, Kobayashi Junya, Mu Anfeng, Takata Minoru

Abstract excerpt

The SLFN11 gene participates in cell fate decision following cancer chemotherapy and encodes the N-terminal ribonuclease (RNase) domain and the C-terminal helicase/ATPase domain. How these domains contribute to the chemotherapeutic response remains controversial. Here, we expressed SLFN11 containing mutations in two critical residues required for RNase activity in SLFN11-/- cells. We found that this mutant was...

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PMID: 37469008
DOI: 10.1111/gtc.13056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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