Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.

The Journal of biological chemistry - 16 Feb 2001

Qiu J, Li X, Frank G, Shen B

Abstract excerpt

Flap endonuclease-1 (FEN-1), a 43-kDa protein, is a structure-specific and multifunctional nuclease. It plays important roles in RNA primer removal of Okazaki fragments during DNA replication, DNA base excision repair, and maintenance of genome stability. Three functional motifs of the enzyme were proposed to be responsible for its nuclease activities, interaction with proliferating cell nuclear antigen, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Replication
Share to Endodeoxyribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flap Endonucleases

Share to G1 Phase

Share to Nuclear Localization Signals

Share to Proliferating Cell Nuclear Antigen

Share to S Phase

Share to Transformation, Genetic

Source

Identifiers

PMID: 11053418
DOI: 10.1074/jbc.M007825200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.PMID 11053418Read ↗

Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.Semantic proximity Read ↗

Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways.Semantic proximity Read ↗

Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.Semantic proximity Read ↗

Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice.Semantic proximity Read ↗

XPF mediates 3' flap processing for FEN1-independent Okazaki fragment maturation.Semantic proximity Read ↗

XPF mediates 3’ flap processing for FEN1-independent Okazaki fragment maturationSemantic proximity Read ↗

Stimulation of eukaryotic flap endonuclease-1 activities by proliferating cell nuclear antigen (PCNA) is independent of its in vitro interaction via a consensus PCNA binding region.Semantic proximity Read ↗

Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks.Semantic proximity Read ↗

The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.Semantic proximity Read ↗

Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function.Semantic proximity Read ↗

Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stability.Semantic proximity Read ↗

Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.