Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis

4 Feb 2025

Abstract excerpt

Impairment of ribosome biogenesis (RiBi) triggered by inhibition of ribosomal RNA (rRNA) synthesis and processing leads to various biological effects. We report that Schlafen 11 (SLFN11) induces TP53-independent apoptosis through RiBi impairment. Upon replication stress, SLFN11 inhibits rRNA synthesis with RNA polymerase I accumulation and increased chromatin accessibility in the ribosomal DNA (rDNA) genes....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to PARP inhibition in cancer therapy
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39909041
DOI: 10.1016/j.molcel.2025.01.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosisPMID 39909041Read ↗

SLFN11-mediated tRNA regulation induces cell death by disrupting proteostasis in response to DNA-damaging agentsSemantic proximity Read ↗

SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243Semantic proximity Read ↗

SLFN11 is a general target for enhancing the sensitivity of cancer to chemotherapy (DNA-damaging agents)Semantic proximity Read ↗

Selective targeting of type II tRNAs underlies SLFN14-mediated translational repression and its dysregulation by thrombocytopenia-linked mutationsSemantic proximity Read ↗

p53 at the crossroad of DNA replication and ribosome biogenesis stress pathwaysSemantic proximity Read ↗

The crucial role of single-stranded DNA binding in enhancing sensitivity to DNA-damaging agents for Schlafen 11 and Schlafen 13Semantic proximity Read ↗

UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosisSemantic proximity Read ↗

Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cellsSemantic proximity Read ↗

SLFN11: a pan-cancer biomarker for DNA-targeted drugs sensitivity and therapeutic strategy guidanceSemantic proximity Read ↗

Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer.Semantic proximity Read ↗

Schlafen 11 (SLFN11) Kills Cancer Cells Undergoing Unscheduled Re-replicationSemantic proximity Read ↗

Ribosomopathies and cancer: pharmacological implicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.