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Article

Interplay of Mre11 nuclease with Dna2 plus Sgs1 in Rad51-dependent recombinational repair.

PloS one - 1 Jan 2009

Budd Martin E, Campbell Judith L

Abstract excerpt

The Mre11/Rad50/Xrs2 complex initiates IR repair by binding to the end of a double-strand break, resulting in 5' to 3' exonuclease degradation creating a single-stranded 3' overhang competent for strand invasion into the unbroken chromosome. The nuclease(s) involved are not well understood. Mre11 encodes a nuclease, but it has 3' to 5', rather than 5' to 3' activity. Furthermore, mutations that inactivate only...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19165339
DOI: 10.1371/journal.pone.0004267
PMCID: PMC2625443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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