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Article

Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication.

World journal of gastroenterology - 28 Aug 2015

Wang Jie, Xu Zhong-Wei, Liu Shuang, Zhang Rui-Yang, Ding Shan-Long, Xie Xiao-Meng, Long Lu, Chen Xiang-Mei, Zhuang Hui, Lu Feng-Min

Abstract excerpt

AIM: To screen and investigate the effective gRNAs against hepatitis B virus (HBV) of genotypes A-D. METHODS: A total of 15 gRNAs against HBV of genotypes A-D were designed. Eleven combinations of two above gRNAs (dual-gRNAs) covering the regulatory region of HBV were chosen. The efficiency of ea...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26327763
DOI: 10.3748/wjg.v21.i32.9554
PMCID: PMC4548116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26327763-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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