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TLK1-mediated RAD54 phosphorylation spatio-temporally regulates Homologous Recombination Repair

29 Jun 2023

Abstract excerpt

Environmental agents like ionizing radiation (IR) and chemotherapeutic drugs can cause severe damage to the DNA, often in the form of double-strand breaks (DSBs). Remaining unrepaired, DSBs can lead to chromosomal rearrangements, and cell death. One major error-free pathway to repair DSBs is homologous recombination repair (HRR). Tousled-like kinase 1 (TLK1), a Ser/Thr kinase that regulates the DNA damage...

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PMID: 37439356
DOI: 10.1093/nar/gkad589

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