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Article

Protein kinase C controls activation of the DNA integrity checkpoint.

Nucleic acids research - 1 Jun 2014

Soriano-Carot María, Quilis Inma, Bañó M Carmen, Igual J Carlos

Abstract excerpt

The protein kinase C (PKC) superfamily plays key regulatory roles in numerous cellular processes. Saccharomyces cerevisiae contains a single PKC, Pkc1, whose main function is cell wall integrity maintenance. In this work, we connect the Pkc1 protein to the maintenance of genome integrity in response to genotoxic stresses. Pkc1 and its kinase activity are necessary for the phosphorylation of checkpoint kinase...

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Identifiers

PMID: 24792164
DOI: 10.1093/nar/gku373
PMCID: PMC4066786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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