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Article

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

Nature cell biology - 1 Oct 2000

Melchionna R, Chen X B, Blasina A, McGowan C H

Abstract excerpt

In response to DNA damage, eukaryotic cells use a system of checkpoint controls to delay cell-cycle progression. Checkpoint delays provide time for repair of damaged DNA before its replication in S phase and before segregation of chromatids in M phase. The Cds1 (Chk2) tumour-suppressor protein has been implicated in certain checkpoint responses in mammalian cells. It directly phosphorylates and inactivates the...

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Identifiers

PMID: 11025670
DOI: 10.1038/35036406

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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