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Article

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.

The EMBO journal - 17 Sept 2008

Morin Isabelle, Ngo Hien-Ping, Greenall Amanda, Zubko Mikhajlo K, Morrice Nick, Lydall David

Abstract excerpt

Exo1 is a nuclease involved in mismatch repair, DSB repair, stalled replication fork processing and in the DNA damage response triggered by dysfunctional telomeres. In budding yeast and mice, Exo1 creates single-stranded DNA (ssDNA) at uncapped telomeres. This ssDNA accumulation activates the checkpoint response resulting in cell cycle arrest. Here, we demonstrate that Exo1 is phosphorylated when telomeres are...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18756267
DOI: 10.1038/emboj.2008.171
PMCID: PMC2532783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.PMID 18756267Read ↗

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DDK has a primary role in processing stalled replication forks to initiate downstream checkpoint signalingSemantic proximity Read ↗

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Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants.Semantic proximity Read ↗

Elevated Levels of the Polo Kinase Cdc5 Override the Mec1/ATR Checkpoint in Budding Yeast by Acting at Different Steps of the Signaling PathwaySemantic proximity Read ↗

Exo1 phosphorylation status controls the hydroxyurea sensitivity of cells lacking the Pol32 subunit of DNA polymerases delta and zeta.Semantic proximity Read ↗

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A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.Semantic proximity Read ↗

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