Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.

doi:10.1038/emboj.2008.171

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Article

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.

The EMBO journal - 17 Sept 2008

Morin Isabelle, Ngo Hien-Ping, Greenall Amanda, Zubko Mikhajlo K, Morrice Nick, Lydall David

Abstract excerpt

Exo1 is a nuclease involved in mismatch repair, DSB repair, stalled replication fork processing and in the DNA damage response triggered by dysfunctional telomeres. In budding yeast and mice, Exo1 creates single-stranded DNA (ssDNA) at uncapped telomeres. This ssDNA accumulation activates the checkpoint response resulting in cell cycle arrest. Here, we demonstrate that Exo1 is phosphorylated when telomeres are...

Topics

Cell Cycle
Cell Cycle Proteins
Checkpoint Kinase 2
DNA Damage
DNA, Single-Stranded
Exodeoxyribonucleases
Fungal Proteins
Genome, Fungal
Genotype
Models, Biological
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Protein Serine-Threonine Kinases

Proteomics

Saccharomyces cerevisiae Proteins

Telomere

Temperature

Source

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Identifiers

PMID: 18756267
DOI: 10.1038/emboj.2008.171
PMCID: PMC2532783

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Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.PMID 18756267Read ↗

The Human Exonuclease-1 Interactome And Phosphorylation SitesSemantic proximity Read ↗

DDK has a primary role in processing stalled replication forks to initiate downstream checkpoint signalingSemantic proximity Read ↗

Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1.Semantic proximity Read ↗

Mec1 and Rad53 inhibit formation of single-stranded DNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants.Semantic proximity Read ↗

Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping.Semantic proximity Read ↗

Exo1 and Rad24 differentially regulate generation of ssDNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants.Semantic proximity Read ↗

Elevated Levels of the Polo Kinase Cdc5 Override the Mec1/ATR Checkpoint in Budding Yeast by Acting at Different Steps of the Signaling PathwaySemantic proximity Read ↗

Exo1 phosphorylation status controls the hydroxyurea sensitivity of cells lacking the Pol32 subunit of DNA polymerases delta and zeta.Semantic proximity Read ↗

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.Semantic proximity Read ↗

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.Semantic proximity Read ↗

A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.Semantic proximity Read ↗

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