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Article

Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors

3 Aug 2018

Abstract excerpt

genes and an association with poor patient outcome in multiple types of cancer, and depletion of TLK activity leads to increased replication stress and DNA damage in a panel of cancer cells. Our results reveal a critical role for TLKs in chromatin replication and suppression of replication stress and identify a synergistic lethal relationship with checkpoint signaling and PARP that could be exploited in treatment...

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PMID: 30101194
DOI: 10.1126/sciadv.aat4985

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