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Article

Methylation Profiling Identifies Stability of Isocitrate Dehydrogenase Mutation Over Time.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques - 1 May 2024

Voisin Mathew R, Gui Chloe, Patil Vikas, Gao Andrew F, Zadeh Gelareh

Abstract excerpt

OBJECTIVE: Isocitrate dehydrogenase (IDH) mutation status is a key diagnostic and prognostic feature of gliomas. It is thought to occur early in glioma tumorigenesis and remain stable over time. However, there are reports documenting a loss of IDH mutation status in a subset of patients with glioma recurrence. Here, we identified patients with a documented loss of IDH mutation status longitudinally and performed...

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Identifiers

PMID: 37434550
DOI: 10.1017/cjn.2023.253
PMCID: PMC11892112

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