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Article

Epigenetic evolution of isocitrate dehydrogenase-wildtype glioblastomas.

Neuro-oncology - 1 Apr 2026

Deng Bo, Head Rania, Draaisma Kaspar, Hoeben Ann, Lukacova Slávka, Lombardi Giuseppe, Leenstra Sieger, Hanse Monique, Fleischeuer Ruth E M, Watts Colin, Angelopoulos Nicos, Gorlia Thierry, Bours Vincent, van den Bent Martin J, Robe Pierre A, Hoogstrate Youri, French Pim J

Abstract excerpt

BACKGROUND: Although the genetic evolution of isocitrate dehydrogenase-wildtype (IDHwt) glioblastomas has extensively been investigated, limited studies have addressed the epigenetic evolution. Understanding the epigenetic evolution is particularly relevant, as demethylation of the MGMT promoter may form a means of treatment resistance. METHODS: We generated whole-genome DNA methylation data of 64 matched...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41485099
DOI: 10.1093/neuonc/noaf298
PMCID: PMC13128464

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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