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Article

From genomics to the clinic: biological and translational insights of mutant IDH1/2 in glioma.

Neurosurgical focus - 1 Feb 2013

Dunn Gavin P, Andronesi Ovidiu C, Cahill Daniel P

Abstract excerpt

The characterization of the genomic alterations across all human cancers is changing the way that malignant disease is defined and treated. This paradigm is extending to glioma, where the discovery of recurrent mutations in the isocitrate dehydrogenase 1 (IDH1) gene has shed new light on the molecular landscape in glioma and other IDH-mutant cancers. The IDH1 mutations are present in the vast majority of...

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Source

Identifiers

PMID: 23373447
DOI: 10.3171/2012.12.FOCUS12355

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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