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Partial inhibition of class III PI3K VPS-34 ameliorates motor aging and prolongs health span

11 Jul 2023

Abstract excerpt

Global increase of life expectancy is rarely accompanied by increased health span, calling for a greater understanding of age-associated behavioral decline. Motor independence is strongly associated with the quality of life of elderly people, yet the regulators for motor aging have not been systematically explored. Here, we designed a fast and efficient genome-wide screening assay in Caenorhabditis elegans and...

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PMID: 37432924
DOI: 10.1371/journal.pbio.3002165

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