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Article

VPS13D mutations affect mitochondrial homeostasis and locomotion in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 17 Apr 2025

Yin Xiaomeng, Wang Ruoxi, Thackeray Andrea, Baehrecke Eric H, Alkema Mark J

Abstract excerpt

Mitochondria control cellular metabolism, serve as hubs for signaling and organelle communication, and are important for the health and survival of cells. VPS13D encodes a cytoplasmic lipid transfer protein that regulates mitochondrial morphology, mitochondria and endoplasmic reticulum contact, and quality control of mitochondria. VPS13D mutations have been reported in patients displaying ataxic and spastic gait...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39957248
DOI: 10.1093/g3journal/jkaf023
PMCID: PMC12005150

Genes

VPS13D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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