Back to search

Article

Anti-Parkinsonian Drugs Rescue Locomotor Deficits in JIP3 Knockout Zebrafish: Implications for Treating Patients with <i>MAPK8IP3</i> -related Neurodevelopmental Disorders

2025-02-06

Abstract excerpt

<h4>ABSTRACT</h4> MAPK8IP3- related neurodevelopmental disorders are a spectrum of rare conditions caused by de novo mutations in the MAPK8IP3 gene that encodes the JIP3 protein. These disorders are associated with a spectrum of neurodevelopmental symptoms that manifest in children and cause brain abnormalities, profound intellectual disabilities, movement disorders, and developmental delays. JIP3 is required f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
500da515-6724-5b65-9ddd-d076299e96ca
DOI
10.1101/2025.02.02.636112
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Anti-Parkinsonian Drugs Rescue Locomotor Deficits in JIP3 Knockout Zebrafish: Implications for Treating Patients with <i>MAPK8IP3</i> -related Neurodevelopmental DisordersDOI 10.1101/2025.02.02.636112
Modeling neuromuscular diseases in zebrafishSemantic proximity
Pathogenic <i>MAPK8IP3</i> variants drive distinct motor and behavioral phenotypes in humans and miceSemantic proximity
Eye movement defects in KO zebrafish reveals SRPK3 as a causative gene for an X-linked intellectual disabilitySemantic proximity
Compound heterozygous variants in MAPK8IP3 were detected in severe congenital hypotonia mimicking lethal spinal muscular atrophy.Semantic proximity
Genetically altered animal models for ATP1A3-related disorders.Semantic proximity
Leigh Syndrome: A Comprehensive Review of Disease, Present and Future TreatmentsSemantic proximity
Diving deep: zebrafish models in motor neuron degeneration researchSemantic proximity
Zebrafish as a novel model to assess Na+/K(+)-ATPase-related neurological disorders.Semantic proximity
Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neuronsSemantic proximity
Integrated Behavioral and Proteomic Characterization of MPP⁺-Induced Early Neurodegeneration and Parkinsonism in Zebrafish LarvaeSemantic proximity
1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine induced Parkinson's disease in zebrafishSemantic proximity
Severe neurometabolic phenotype in <i>npc1</i> <sup>-/-</sup> zebrafish with a C-terminal mutationSemantic proximity
Select a neighboring publication to make it the new centre.