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Article

PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans.

Oncotarget - 2 Aug 2016

Ayyadevara Srinivas, Balasubramaniam Meenakshisundaram, Johnson Jay, Alla Ramani, Mackintosh Samuel G, Shmookler Reis Robert J

Abstract excerpt

Class-I phosphatidylinositol 3-kinase (PI3KI) converts phosphatidylinositol 4,5-bisphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3). PIP3 comprises two fatty-acid chains that embed in lipid-bilayer membranes, joined by glycerol to inositol triphosphate. Proteins with domains that specifically bind that head-group (e.g. pleckstrin-homology [PH] domains) are thus tethered to the inner...

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Identifiers

PMID: 27429199
DOI: 10.18632/oncotarget.10549
PMCID: PMC5226477

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