Article
Dynamic heterogeneity: isolation of murine tumor cell populations enriched for metastatic variants and quantification of the unstable expression of the phenotype.
Clinical & experimental metastasis - 1 Jan 2000
Young S D, Hill R P
Abstract excerpt
Recent studies have indicated that KHT fibrosarcoma or B16 melanoma cell variants capable of forming experimental metastases in the lungs of mice after i.v. injection are created stochastically at high rates (approximately 10(-5)/cell/generation). Expression of this phenotype is unstable and hence expanding populations of tumor cells establish a dynamic equilibrium between a small subpopulation of metastatic...
Topics
- Animals
- Cell Line
- Cell Separation
- Female
- Fibrosarcoma
- Lung
- Lung Neoplasms
- Male
- Melanoma
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL