Article
Invasive and metastatic capacity of revertants of LFA-1-deficient mutant T-cell hybridomas.
Cancer research - 15 Jun 1990
Roosien F F, de Kuiper P E, de Rijk D, Roos E
Abstract excerpt
From the highly metastatic TAM2D2 T-cell hybridoma we have previously generated three independent mutants that were deficient in the surface expression of the adhesion molecule Leukocyte Function-associated Antigen 1 (LFA-1). Both the invasive capacity and the metastatic potential of these mutants were greatly reduced compared with TAM2D2 cells (F.F. Roossien et al., J. Cell Biol., 108: 1979-1985, 1989). We now...
Topics
- Antigens, Differentiation
- Cell Separation
- Flow Cytometry
- Leukocyte-Adhesion Deficiency Syndrome
- Lymphocyte Function-Associated Antigen-1
- Mutation
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Receptors, Leukocyte-Adhesion
- Tumor Cells, Cultured